Zanesville is a city in Muskingum County, Ohio, United States. The population was 25,586 at the 2000 census. In 2006, population was estimated at 25,361. It is the county seat of Muskingum County.6
Zanesville was settled in 1797 by Ebenezer Zane (who lent his name to the town) and his son-in-law, John McIntire, at the point where Zane's Trace met the Muskingum River. Novelist Zane Grey was a descendant of the Zane family and was born in Zanesville. The city was the second state capital of Ohio from 1810 to 1812[http://columbia.tfd.com/Zanesville]. The National Road ran through Zanesville.